Multi-Objective Generative Flow Networks

High-Resolution Genome-Wide Mapping of Chromosome-Arm-Scale Truncations Induced by CRISPR-Cas9 Editing

We performed an arrayed CRISPR-Cas9 scan of the genome in primary human cells, targeting 17,065 genes for knockout with 101,029 guides.

RxRx3: Phenomics Map of Biology

Here we release RxRx3, the first ever public high-content screening dataset combining genome-scale CRISPR knockouts with multiple-concentration screening of small molecules (a set of FDA-approved and commercially available bioactive compounds).

A Molecular Foundation Model for Drug Discovery

Building and Benchmarking Representations of Life

The continued scaling of genetic perturbation technologies combined with high-dimensional assays (microscopy and RNA-sequencing) has enabled genome-scale reverse-genetics experiments that go beyond single-endpoint measurements of growth or lethality.

Mapping Biology With a Unified Representation Space for Genomic and Chemical Perturbations to Enable Accelerated Drug Discovery